Do this once per case

0 · NotebookLM Setup

Upload the case report as the only source in a new notebook, then run this before anything else.

0.1Source Grounding & Data Completeness#setup

Using only the uploaded case as your source, confirm: (1) patient age/sex/presenting complaint, (2) the stage-by-stage sequence of events as documented (presentation → history/exam → workup → intervention → outcome), (3) which data types are present (history, exam, labs, imaging, medications, progression notes), (4) any obvious gaps in the documentation, and (5) information a clinician would normally want at presentation that is not recorded in the source. Flag anything you infer versus anything explicitly stated.

  1. 1Using only the uploaded case as your source, confirm the patient's age, sex, and presenting complaint.
  2. 2Using only the uploaded case as your source, lay out the stage-by-stage sequence of events as documented: presentation, history/exam, workup, intervention, outcome.
  3. 3Using only the uploaded case as your source, list which data types are present: history, exam, labs, imaging, medications, progression notes.
  4. 4Using only the uploaded case as your source, identify any obvious gaps in the documentation.
  5. 5Using only the uploaded case as your source, list information a clinician would normally want at presentation that is not recorded in the source, and flag anything you infer versus anything explicitly stated.
Note on gaps: if a prompt below asks for something your source doesn't contain, NotebookLM should say so rather than invent it. "Not documented in source" is a correct answer, not a failed prompt.

Tier 1 · Recall · Mechanism · Glossary · Illness Script

1 · Intern Lens

Build the scaffolding. Unpack every jargon term and decision into the mechanism behind it — don't just accept that a step was taken, understand why it was valid.

Studio tool pairing: after these prompts, use the Studio panel's Flashcards and Quiz generators on this notebook for spaced recall drilling of the glossary and problem list.
1.1Chart Recall & Illness Script#intern

From the uploaded case only: (1) Summarize the history of presenting illness in 3 sentences. (2) List all active problems as a problem list. (3) List all current medications with dose/route/frequency as documented. (4) Pull out the 5 most abnormal lab or vital sign values and state the normal range for each. (5) State what a "textbook" illness script for the leading diagnosis looks like, and note where this case matches or deviates from it.

  1. 1From the uploaded case only, summarize the history of presenting illness in 3 sentences.
  2. 2From the uploaded case only, list all active problems as a problem list.
  3. 3From the uploaded case only, list all current medications with dose, route, and frequency as documented.
  4. 4From the uploaded case only, pull out the 5 most abnormal lab or vital sign values and state the normal range for each.
  5. 5From the uploaded case only, state what a textbook illness script for the leading diagnosis looks like, and note where this case matches or deviates from it.
1.2Jargon & Mechanism Glossary#glossary

Acting as if teaching a new intern: (1) List every clinical term, abbreviation, scoring system, or named threshold used in this case and define each in one or two sentences, including the specific numeric value or range relevant here. (2) For every test ordered or treatment given in the case, explain the underlying physiological or pharmacological mechanism that makes it the correct move at that point — not just what was done, but why it works.

  1. 1Acting as if teaching a new intern, list every clinical term, abbreviation, scoring system, or named threshold used in this case and define each in one or two sentences, including the specific numeric value or range relevant here.
  2. 2Acting as if teaching a new intern, for every test ordered or treatment given in this case, explain the underlying physiological or pharmacological mechanism that makes it the correct move at that point — not just what was done, but why it works.
1.3Blind Differential & Can't-Miss Diagnoses#cant-miss

Using only the information present at the initial presentation stage of this case — not the final diagnosis — (1) list the differential a clinician should have considered at that point. (2) Separately, list the dangerous "can't-miss" diagnoses that present similarly to this chief complaint in general, even ones this case does not turn out to be, so the pattern generalizes beyond this one patient.

  1. 1Using only the information present at the initial presentation stage of this case, not the final diagnosis, list the differential a clinician should have considered at that point.
  2. 2List the dangerous can't-miss diagnoses that present similarly to this chief complaint in general, even ones this case does not turn out to be, so the pattern generalizes beyond this one patient.
1.4Self-Quiz#quiz

Quiz me: ask me one question at a time about this case's key facts and the glossary terms we just covered. Wait for my answer before giving the next question. Tell me if I got it right before moving on.

Self-check

Tier 2 · Judgment · Decision Points · Deviation

2 · Resident Lens

The mechanism is assumed known. Focus on where reasonable clinicians could branch differently, why this path was chosen, and how this case links into the wider network of similar presentations.

Studio tool pairing: generate a Mind Map from the notebook to visualize how each differential branches from specific findings — useful for spotting where two diagnoses share a root finding but diverge downstream.
2.1Ranked Differential & Probability Shift#resident

Based only on the uploaded case: (1) Generate a ranked differential diagnosis (top 5) with one supporting and one refuting data point for each, drawn from the source. (2) Explain how the ranking of that differential shifted as each new finding came in — which single finding did the most work narrowing it down? (3) Identify the single most useful next investigation to discriminate between the top two, and explain why it beats the alternatives. (4) Flag any drug-drug or drug-disease interaction risk in the current medication list.

  1. 1Based only on the uploaded case, generate a ranked differential diagnosis (top 5) with one supporting and one refuting data point for each, drawn from the source.
  2. 2Based only on the uploaded case, explain how the ranking of the differential shifted as each new finding came in — which single finding did the most work narrowing it down?
  3. 3Based only on the uploaded case, identify the single most useful next investigation to discriminate between the top two diagnoses, and explain why it beats the alternatives.
  4. 4Based only on the uploaded case, flag any drug-drug or drug-disease interaction risk in the current medication list, using only what's in the source.
2.2Decision Points & Deviation Analysis#deviation

Identify 2-4 moments in this case where a reasonable clinician could have gone a different direction. For each: (1) state the path actually taken, (2) state a reasonable alternative, (3) explain why this path was chosen over the alternative. Then: where did management follow standard guideline/textbook approach, and where did it diverge — and was that divergence justified by an atypical feature of this patient, or is it arguably a pitfall worth flagging?

  1. 1Identify 2-4 moments in this case where a reasonable clinician could have gone a different direction, stating the path actually taken and a reasonable alternative for each.
  2. 2For each decision point identified, explain why this path was chosen over the alternative.
  3. 3State where management in this case followed standard guideline/textbook approach, and where it diverged — and whether that divergence was justified by an atypical feature of this patient, or is arguably a pitfall worth flagging.
2.3Devil's Advocate#devils-advocate

Play devil's advocate: challenge my leading diagnosis. Give me the strongest argument, drawn from this case's actual data, for why an alternative diagnosis on the list could be right instead. Make me defend my choice before agreeing or disagreeing.

2.4Cross-Case Integration#cross-case

What other conditions or presentations does this case overlap with clinically? For each overlapping condition, state the single discriminating feature that would separate it from this case's actual diagnosis, so this case connects into a broader network rather than staying an isolated example.

2.5Overnight Deterioration Drill#overnight-challenge

If this patient deteriorated overnight based on the trajectory in the notes, walk me through: (1) what bedside check I'd do first, (2) what immediate step I'd take, (3) at what point I'd escalate — reasoning only from what's documented, not hypotheticals outside the source.

  1. 1If this patient deteriorated overnight based on the trajectory in the notes, tell me what bedside check I'd do first — reasoning only from what's documented.
  2. 2If this patient deteriorated overnight based on the trajectory in the notes, tell me what immediate step I'd take — reasoning only from what's documented.
  3. 3If this patient deteriorated overnight based on the trajectory in the notes, tell me at what point I'd escalate — reasoning only from what's documented.
Self-check

Optional closing step · run after both tiers

3 · Cross-Level Synthesis

Consolidate the session — see how the reasoning actually changed as you moved from Intern to Resident lens.

3.1Session Synthesis#synthesis

Compare how the answers changed across the Intern-lens and Resident-lens prompts I ran on this case. (1) What did the Resident lens add that the Intern lens didn't? (2) Where did Intern-level reasoning turn out to be incomplete or need revision at the Resident level? (3) What's the one thing worth remembering from each lens for this case?

  1. 1Compare how the answers changed across the Intern-lens and Resident-lens prompts I ran on this case: what did the Resident lens add that the Intern lens didn't?
  2. 2Where did Intern-level reasoning on this case turn out to be incomplete or need revision at the Resident level?
  3. 3What's the one thing worth remembering from each lens — Intern and Resident — for this case?

Run last · builds a reusable, searchable output

4 · Pearl Bank Extraction

Pull the takeaways out of this single case into a tagged format, so pearls accumulate across every case you run through this workflow instead of staying trapped in one notebook.

4.1Tagged Pearl Extraction#pearl-bank

From everything discussed in this notebook, extract 2-3 Intern pearls and 2-3 Resident pearls. Intern pearls should be mechanism-anchored and generalizable, in the format "[Finding/pattern] leads to [action], because [mechanism]." Resident pearls should be judgment-anchored, in the format "[Situation] means deviating from the standard approach when [condition], because [reasoning]." Output each pearl as a single row in this format: Organ system | Topic | Pearl type (Intern/Resident) | Pearl text

Building the bank: paste each session's output rows into one running document or spreadsheet, tagged by organ system and topic. Over enough cases this becomes a searchable, personal knowledge base rather than isolated notebook sessions.

Documentation practice · any tier

5 · SOAP Note Practice

Translate the case into standard clinical documentation format — a disciplined write-up exercise, distinct from the reasoning tiers above.

5.1SOAP Note#soap

Using only the uploaded case, write a SOAP note: (1) Subjective — the presenting complaint and history as documented. (2) Objective — vitals, exam findings, and lab/imaging results as recorded. (3) Assessment — the working diagnosis or problem list as it stands in the source. (4) Plan — next steps, treatments, and follow-up as documented, distinguishing completed actions from pending ones.

  1. 1Using only the uploaded case, write the Subjective section of a SOAP note — the presenting complaint and history as documented.
  2. 2Using only the uploaded case, write the Objective section of a SOAP note — vitals, exam findings, and lab/imaging results as recorded.
  3. 3Using only the uploaded case, write the Assessment section of a SOAP note — the working diagnosis or problem list as it stands in the source.
  4. 4Using only the uploaded case, write the Plan section of a SOAP note — next steps, treatments, and follow-up as documented, distinguishing completed actions from pending ones.
Self-check