Dr. Avinash kumar gupta

VibeRounds — Master Case Analysis Protocol

Framework Source: VibeRounds Combined Modules 1–20 Protocol Version: 1.1 — June 2026 Validated Against: 60F with Coma, E Coli Sepsis, Cervical Myelopathy, and Albumino-Cytological Dissociation in CSF Changelog (v1.0 → v1.1): Added Stage 7 — Further Requested Information Synthesis, and a new fourth output file (VibeRounds-FurtherInfo-[CaseName].md) that consolidates every history, examination, and investigation gap surfaced anywhere in Stages 1–6 into one prioritized, actionable list. See Protocol Maintenance Notes at the end of this file for the full rationale.


How to Use This Protocol

  1. Upload this file to Claude (or any capable LLM) along with the VibeRounds Modules 1–20 file.
  2. Paste a case link (public blog, open patient record, or de-identified case narrative URL) in your message.
  3. Send the trigger prompt at the bottom of this document.
  4. The AI will execute all seven pipeline stages in sequence and deliver four output .md files:
    • VibeRounds-TopInsights-[CaseName].md — Top 10 clinical insights (standalone, shareable summary)
    • VibeRounds-CaseAnalysis-[CaseName].md — Prompt mapping, ranking, and full high-value prompt answers
    • VibeRounds-CARE-AdvocateDebrief-[CaseName].md — CARE case report and advocate debrief
    • VibeRounds-FurtherInfo-[CaseName].md(New in v1.1) Consolidated, prioritized list of further history, examination, and investigation details that would be high-value to obtain, with the reasoning for each

Data Safety Note: Only use de-identified or consent-obtained public case records. Do not paste identifying information (full name, date of birth, address, hospital number) into any LLM session. This protocol is an educational tool, not a clinical decision-making service. All outputs require independent clinical verification before any action is taken.


Pipeline Overview

INPUT
  ├── VibeRounds Modules 1–20 (uploaded file)
  └── Case link or narrative (provided by user)
         │
         ▼
  STAGE 1 — Case Ingestion
  Read and extract structured clinical details from the case source
  (flags information gaps as [NOT DOCUMENTED] — these feed Stage 7)
         │
         ▼
  STAGE 2 — Prompt Mapping
  Match VibeRounds prompts from all 20 modules to the patient's clinical features
         │
         ▼
  STAGE 3 — Prompt Ranking
  Rank all matched prompts 1–10 on clinical importance for this specific case
         │
         ▼
  STAGE 4 — High-Value Prompt Execution
  Answer all prompts rated 8–10 in full clinical depth
  (each answer may surface its own information gaps — tag inline, feed Stage 7)
         │
         ▼
  STAGE 5 — Insight Synthesis
  Extract the top 10 clinical insights from all analysis above
         │
         ▼
  STAGE 6 — CARE Report + Advocate Debrief
  Produce CARE-format case write-up and structured advocate journey analysis
  (CARE 5c "missing investigations" and debrief inflection points feed Stage 7)
         │
         ▼
  STAGE 7 — Further Requested Information Synthesis  (NEW in v1.1)
  Pool every flagged gap from Stages 1, 4, and 6 into one deduplicated,
  prioritized, actionable request list
         │
         ▼
OUTPUT
  ├── File 1: VibeRounds-TopInsights-[CaseName].md
  ├── File 2: VibeRounds-CaseAnalysis-[CaseName].md
  ├── File 3: VibeRounds-CARE-AdvocateDebrief-[CaseName].md
  └── File 4: VibeRounds-FurtherInfo-[CaseName].md          (NEW in v1.1)

Stage Specifications


STAGE 1 — Case Ingestion

Objective: Extract a complete, structured summary of the clinical case from the provided source.

Instructions for AI:

Patient demographics: age, sex, occupation, social/geographical background
Chief complaint and mode of presentation
Background history (duration, prior diagnoses, prior treatments)
Symptom timeline (chronological — when each symptom appeared or changed)
Medications (name, dose, frequency, route, duration, any self-modifications)
Examination findings (vitals, systemic, neurological, others)
Investigations (results, dates where available, units)
Procedures performed
Working diagnoses at presentation
Management given
Outcome
Investigations NOT performed but clinically indicated
Patient/advocate narrative (if present)

Quality gate before proceeding: Confirm the case has enough clinical content to support at least 8 usable VibeRounds prompts. If not, flag this and ask the user for additional case detail before continuing.

Stage 7 hand-off (NEW in v1.1): Every field marked [NOT DOCUMENTED] in this stage is a candidate entry for the Stage 7 information request list. Do not discard these — carry the field name and a one-line note on why it matters forward into a running “gap log” that Stage 7 will consolidate. This running gap log is internal working scratch, not a deliverable in itself — it only needs to persist within the session/context so Stage 7 can pool it.


STAGE 2 — Prompt Mapping

Objective: Identify every VibeRounds prompt across Modules 1–20 that is directly applicable to this patient’s clinical features.

Instructions for AI:

Mapping triggers by module (reference guide):

Module Triggered when case has…
M1 — Socratic Clinical Reasoning Any diagnostic uncertainty; reasoning gaps; learning context
M2 — Patient-Advocate Documentation Family/caregiver narrative present; non-medical documentation of course
M3 — Extended Monitoring Longitudinal deterioration over weeks/months documented
M4 — Ward Round Preparation Acute admission; multi-system complexity; handover moments
M5 — Real-Time Case Review Longitudinal data (glucose logs, medication logs, serial bloods)
M6 — Registry Analytics Population-level patterns implied; case belongs to a known registry
M7 — Cross-Case Learning Similar cases exist or are mentioned; registry context
M8 — Socratic Design QA Session being designed for teaching; prompt quality review needed
M9 — N-of-1 Research Protocol Complex, multi-system, unusual case suitable for case report
M10 — Article Reading Specific paper directly relevant to case findings
M11 — Patient Education Patient/family information needs visible in narrative
M12 — Differential Diagnosis Deepdive Working diagnosis formed but contested; anchoring risk present
M13 — Polypharmacy Audit 5+ medications; drug-disease conflicts; prescribing cascade risk
M14 — Resource-Constrained Reasoning Investigations unavailable; transport limitations; low-resource setting
M15 — Illness Script Acquisition Typical/atypical presentation; script mismatch visible
M16 — Basic Science Integration Mechanism-to-diagnosis link important for this case
M17 — Semantic Qualifiers Problem representation needs to be corrected or sharpened
M18 — Causal Network Reasoning Multiple findings interact conditionally; one finding changes weight of another
M19 — Community & Social Medicine Social determinants of health visible; occupation/environment relevant
M20 — Recognition-Primed Decision Time-critical moment present; acute deterioration; stat call scenario

STAGE 3 — Prompt Ranking

Objective: Rank all mapped prompts by clinical importance for this specific case.

Instructions for AI:


STAGE 4 — High-Value Prompt Execution

Objective: Answer every prompt scored 8–10 in full clinical depth, applied specifically to this patient.

Instructions for AI:

Minimum answer length per high-value prompt: Sufficient to be clinically actionable. A bulleted list of five words is not an answer. A paragraph that names the mechanism, the clinical consequence, and the action is the minimum standard.

Stage 7 hand-off (NEW in v1.1): Many high-value answers will, in the course of full clinical reasoning, surface a piece of missing history, an examination step that was never documented as performed, or an investigation that would resolve a stated uncertainty (this is most likely from Module 12 differential challenges, Module 13 polypharmacy audits, Module 14 resource-reasoning, Module 18 network reasoning, and Module 20 escalation-threshold answers). Whenever this happens, append one line to the running gap log in the format:

[GAP] <Module.Step> | <what is missing> | <why it would change the answer>

This tagging is lightweight and internal — it does not change the formatting of the Stage 4 answer itself, it just marks the gap for Stage 7 pooling.


STAGE 5 — Insight Synthesis

Objective: Extract the top 10 clinical insights from all analysis above.

Instructions for AI:


STAGE 6 — CARE Report + Advocate Debrief

Objective: Produce two structured documents — a CARE-format case report and a structured advocate journey debrief.


6A — CARE-Format Case Report

Follow all 12 CARE guideline fields in sequence:

1. Title Format: [Age][Sex] with [chief complaint(s)] and [key investigation finding]: [educational contribution of case]

2. Abstract Four paragraphs: Background (why this case matters clinically) | Case Summary (≤150 words) | Key Learning Points (numbered, minimum 3) | Conclusion (one sentence on the educational contribution)

3. Introduction Why this case is clinically and educationally important. What gap in practice it exposes. What it contributes that existing literature does not.

4. Patient Information Structured table: demographics, occupation, social/geographical background, comorbidities, prior diagnoses.

5. Clinical Findings Two sub-sections:

6. Timeline Chronological flow diagram or structured timeline from first symptoms to outcome, with each major clinical event, decision point, and missed pivot labelled.

7. Diagnostic Assessment

8. Therapeutic Interventions Table: intervention | timing | rationale | outcome. Include a separate row for each intervention that was NOT initiated but was indicated, with justification.

9. Follow-Up and Outcomes What happened. If fatal: what post-mortem data was or was not obtained, and what that means for learning.

10. Discussion Three to four named teaching points, each structured as: what happened → what should have happened → why the gap occurred → what would prevent it.

11. Patient Perspective Reconstructed from any patient or advocate narrative in the case source. If none exists, mark as [Not documented — patient perspective unavailable].

12. Informed Consent Statement Source and consent status of the case material.


6B — Advocate Debrief

Structure:

Opening: What is an advocate debrief? One paragraph defining its purpose — not criticism of the family, but clinical systems analysis of what healthcare encounters failed to provide.

The Advocate’s Role: What specific roles did the family caregiver play in this case? (Historian, medication administrator, wound care coordinator, decision-maker, etc.)

Inflection Point Analysis: For each major clinical turning point in the case (minimum 5 inflection points), produce:

### Inflection Point [N] — [Name of moment]
**What happened:** [clinical event]
**What the advocate understood:** [their likely interpretation]
**What the advocate needed to know:** [specific information, in plain language]
**The question the advocate needed to ask:** [exact wording they could have used]
**VibeRounds module applied:** [Module X, Step Y]
[Module 11-style red flag table or Module 2-style information brief where applicable]

What the Advocate Did Well: Explicit acknowledgement of what the family managed correctly — this section is mandatory and must not be omitted.

Advocate Learning Summary: Apply Module 2 Step 2.8 (Bloom’s Remember → Understand → Apply) as three questions and model answers the advocate should have been able to answer at discharge.

Recommendations for Future Similar Cases: Four to six specific, actionable recommendations — for the clinical team, for the prescribing clinician, for the discharge process, and for the healthcare system.

Stage 7 hand-off (NEW in v1.1): Two specific elements of Stage 6 are required Stage 7 inputs, not optional ones:

Add both to the running gap log using the same [GAP] tag format as Stage 4, e.g. [GAP] CARE-5c | <investigation> | <why> or [GAP] Inflection-3 | <history detail> | <why>.


STAGE 7 — Further Requested Information Synthesis (NEW in v1.1)

Objective: Consolidate every history detail, examination finding, and investigation that is missing from the case but would be high clinical value to obtain — pooled from across the entire pipeline — into one deduplicated, prioritized, actionable request list.

Why this stage exists: Stages 1, 4, and 6 each surface information gaps independently and for different reasons (Stage 1 — simple absence from the source record; Stage 4 — a gap that blocks full resolution of a high-value clinical question; Stage 6 — a gap named explicitly in CARE 5c or needed by the advocate at a specific inflection point). Without a synthesis stage, these gaps stay scattered across three different files in three different formats, and the single most clinically actionable output of the whole pipeline — “if I could ask one more thing, what would move this case forward most” — never gets assembled. Stage 7 closes that loop.

Instructions for AI:

  1. Pool. Collect every [GAP] tag logged during Stages 1, 4, and 6, plus every field marked [NOT DOCUMENTED] in the Stage 1 structured extraction, plus every “investigation required” entry from the CARE 7 differential table.
  2. Deduplicate. Where the same underlying missing item was flagged from multiple stages (e.g. a missing CSF culture flagged in both Stage 4’s Module 12 differential challenge and CARE 5c), merge into a single entry and retain all contributing reasons.
  3. Classify each pooled gap into exactly one of three categories:
    • History — symptom detail, timeline clarification, exposure/occupational/travel history, medication history, family history, prior-episode history
    • Examination — a physical or neurological examination component not documented as performed, or performed but with an undocumented result
    • Investigation — a laboratory test, imaging study, procedure, or specialist referral not performed or pending
  4. Score each gap 1–10 on the same clinical-importance scale used in Stage 3, with this Stage-7-specific anchor:
    • 10 — Obtaining this would likely resolve the central unanswered diagnostic question in CARE field 7
    • 8–9 — Obtaining this would materially change risk stratification, treatment choice, or escalation decision
    • 6–7 — Obtaining this would strengthen confidence in the working diagnosis or rule out a credible differential
    • 4–5 — Useful for completeness or longitudinal tracking; unlikely to change current management
    • 1–3 — Low yield; included for completeness only
  5. For each gap, state:
    • The specific item requested, phrased as something a clinician could actually ask or order (not vague — “ask about recent antibiotic exposure in the 4 weeks prior to admission,” not “more history needed”)
    • Which stage(s)/module(s) flagged it (traceability back to Stages 1, 4, or 6)
    • What specific question this would answer or what differential it would help resolve/exclude
    • Who is best placed to obtain it (bedside clinician, family/advocate, specialist referral, laboratory)
  6. Sort descending by score within each of the three categories (History / Examination / Investigation).
  7. Cap and prioritize. If the pooled, deduplicated list exceeds 20 items, retain all items scored 8–10 in full, and group items scored below 8 into a shorter “Lower-yield / completeness” appendix list rather than dropping them.

Output format — table per category:

| Score | Item Requested | Flagged By (Stage/Module) | Resolves/Excludes | Best Placed To Obtain |

Quality gate before proceeding to file writing: Confirm every item in CARE field 5c (“explicitly flag missing investigations”) and every Stage 4 [GAP] tag has a corresponding row in this stage’s output. If any flagged gap from an earlier stage is missing here, go back and add it before writing File 4 — Stage 7 must be a complete pool, not a re-summary.


Output File Specifications

File 1: VibeRounds-TopInsights-[CaseName].md

Purpose: A standalone, shareable summary of the most important clinical learning from this case. Designed to be read independently — without needing to open the full analysis file.

Contains:

File 2: VibeRounds-CaseAnalysis-[CaseName].md

Contains:

File 3: VibeRounds-CARE-AdvocateDebrief-[CaseName].md

Contains:

File 4: VibeRounds-FurtherInfo-[CaseName].md (NEW in v1.1)

Purpose: A standalone, actionable “what to ask/examine/order next” reference — the single file a clinician or advocate would consult if the case were still live and they wanted to know what to do next to close the most important information gaps. Designed to be read independently.

Contains:

Naming convention: [CaseName] = abbreviated identifier derived from the case (e.g., 60F-EColi-Sepsis, 45M-DKA-Tropical, 72F-Dementia-Falls). Use age + sex + two to three key clinical features, hyphen-separated, no spaces. The same [CaseName] is used across all four output files.


Quality Checks Before Delivering Output

Before writing any output file, the AI must confirm:


Trigger Prompt

Copy and send this prompt to Claude (with this protocol file and the VibeRounds Modules 1–20 file uploaded):


#VibeRounds Run the full Master Case Analysis Protocol (v1.1) on the following case:

[PASTE CASE LINK OR CASE NARRATIVE HERE]

Execute all seven pipeline stages in sequence:
Stage 1 — Case ingestion and structured extraction (log all [NOT DOCUMENTED] fields)
Stage 2 — Prompt mapping across all 20 modules
Stage 3 — Prompt ranking by clinical importance (1–10)
Stage 4 — Full answers to all prompts scored 8–10 (tag any [GAP] surfaced along the way)
Stage 5 — Top 10 clinical insights
Stage 6 — CARE-format case report (all 12 fields) + Advocate debrief (all sections; tag any [GAP] from CARE 5c or inflection points)
Stage 7 — Pool all logged gaps into a prioritized Further Requested Information synthesis

Deliver four output .md files:
File 1: VibeRounds-TopInsights-[CaseName].md
File 2: VibeRounds-CaseAnalysis-[CaseName].md
File 3: VibeRounds-CARE-AdvocateDebrief-[CaseName].md
File 4: VibeRounds-FurtherInfo-[CaseName].md

Follow all quality checks in the protocol before writing the output files.
State which stage you are in before beginning each one.
Do not collapse stages or skip ahead.

What This Protocol Is and Is Not

This protocol IS:

This protocol IS NOT:


Protocol Maintenance Notes

This protocol was developed and validated in June 2026 against one complex multi-system case. As additional cases are run through the pipeline, the following should be updated:

Rationale for v1.1 Change

The original six-stage pipeline produced excellent retrospective analysis (what happened, what it meant, what should have happened) but left “what should be asked/examined/ordered next” scattered as a side-effect across three different files in three different formats (Stage 1’s [NOT DOCUMENTED] tags, CARE field 5c, and individual advocate inflection points). For an educational tool whose stated purpose includes surfacing diagnostic gaps, this scattering meant the single most actionable output — a prioritized list of what would move the case forward — was never actually assembled anywhere. Stage 7 and File 4 close that gap by treating “further requested information” as a first-class pipeline output with its own dependency chain, rather than an incidental by-product of other stages. See the companion file VibeRounds-Dependency-Network-Map.md for the full inter-stage dependency structure this introduces.


VibeRounds Master Case Analysis Protocol v1.1 — June 2026 All outputs generated using this protocol are educational. Independent clinical verification is required before acting on any content. This protocol does not constitute clinical advice, diagnostic guidance, or a substitute for professional medical judgment.